𝕀n this exercise, you will use LD score regression method to calculate the chip heritability of two GWAS phenotypes from the UK Biobank data and look for evidence of population stratification. […] To get started on using the software for this problem, you may find this document helpful … Read more →

𝔻efine the following terms. You can use the definitions in the Sud et al review but use your own words. Provide a one-sentence summary definition and if you need more, write a longer multiple-sentence definition as well. heritability relative risk Mendelian disease cancer susceptibility genes … Read more →

𝕙ttps://uchicago.box.com/s/iqxg6yo7pi50hyudnfcv2xnhtfp6euv8 […] The genetic relatedness matrix (which can be used to calculate heritability and also to adjust for relatedness and population structure) encodes the structure of the data. To get an intuitive sense of how that works, let’s do the … Read more →

ℙroblem Set #1 Due on January 22nd by 1:50 pm Please email your pset answers to me (emcintire@uchicago.edu) with last week’s lab answers together as a single PDF. […] (10 points) Early onset Alzheimer’s disease is very rare; for illustrative purposes, assume it is 0.1% among adults aged … Read more →