Lecture 5

Haky Im

2021-04-12

Categories: Lecture

Learning Objectives

  • Identify effects of population structure on GWAS
  • Interpret principal components of the genotype matrix
  • Correct for population structure
  • Define chip heritability

References

  • Mills, Melinda C.; Barban, Nicola; Tropf, Felix C.. An Introduction to Statistical Genetic Data Analysis (p. 237). MIT Press. Kindle Edition.

  • J. Novembre, et al “Genes mirror geography within Europe,” Nature, vol. 456, no. 7218, pp. 98–101, Aug. 2008.

  • Auton, A., Altshuler, D. M., Durbin, R. M., Chakravarti, A., Clark, A. G., Donnelly, P., et al. (2015). A global reference for human genetic variation. Nature, 526(7571), 68–74. http://doi.org/10.1038/nature15393

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Citation

For attribution, please cite this work as

Haky Im (2021). Lecture 5. BIOS 25328 Cancer Genomics Class Notes. /post/2021/04/12/lecture-5/

BibTeX citation

@misc{
  title = "Lecture 5",
  author = "Haky Im",
  year = "2021",
  journal = "BIOS 25328 Cancer Genomics Class Notes",
  note = "/post/2021/04/12/lecture-5/"
}