Learning Objectives

  • Describe polygenic additive model
  • Identify connection with mixed effects models
  • Explain methods that predict complex traits from genotype data
  • Describe PRS
  • Describe issues with PRS

Slides

https://docs.google.com/presentation/d/11oe2nZIFqs9TOXT_QDqdpsFhZYJeVVLm/edit?usp=sharing&ouid=100565019341850449624&rtpof=true&sd=true

References

See slides

Reuse

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Citation

For attribution, please cite this work as

Haky Im (2022). Lecture 7 - Predicting Complex Diseases - PRS. BIOS 25328 Cancer Genomics Class Notes. /post/2022/04/18/lecture-7-predicting-complex-diseases-prs/

BibTeX citation

@misc{
  title = "Lecture 7 - Predicting Complex Diseases - PRS",
  author = "Haky Im",
  year = "2022",
  journal = "BIOS 25328 Cancer Genomics Class Notes",
  note = "/post/2022/04/18/lecture-7-predicting-complex-diseases-prs/"
}